AZOXIMERI BROMIDUM - PROTECTIVE ACTION OF IMMUNOSTIMULATOR DRUG IN EXPERIMENTAL TRICHINOSIS OF MICE

Abstract

Trichinosis is a parasitic disease caused by roundworms of the Trichinella type.
Geographic distribution - worldwide. Nematodes of the genus Trichinella are one
of the most widespread zoonotic pathogens on the world, and they can still cause
major public health problems in many parts of the world. In our study we evaluated
the protective effect of azoximeri bromidum in experimental trichinosis of mice.
The azoximeri bromidum, is a polymer, a combined innovative product with
immunomodulating, detoxifying, and antioxidative action, it is part of the Russian
influenza vaccine. An assay was carried out on 20 white outbred mice weighting
16-18 g, divided into 2 groups of 10 animals in each. The first group was injected
with azoximeri bromidum; the second group was injected with 0.9% NaCl. The
drug was injected twice with an interval of 48 hours intramuscularly in a dose of
0,004 mg/mouse. After 48 hours the mice were infected by Trichinella spiralis
larvae in a dose of 80±5 larvae/mouse. Analysis of the data indicates that in the
experiment the application of this drug had significant protective effect. The
number of T. spiralis larvae detected in animals was 142.5±11.1 larvae/mouse,
respectively. This was 31.5 times less than in the mice of control group (4485 ±
430.6 larvae/mouse). Based on this, we consider it is expedient to continue the
study of this immunostimulator drug in the complex immunoprophylaxis of
trichinosis.