Marija Obradović, Olivera Dolić, Slava Sukara, Jovan Vojinović


Objective: The aim of this study was to examine the impact of fluoride varnish and a new generation of nanoapatite varnish containing both Casein PhosphoPeptide − Amorphous Calcium Phosphate (CPP-ACP) and fluoride, on the activity of the initial smooth surface caries lesions of primary teeth.

Materials and Methods: A randomized clinical trial was conducted on a total of 120 primary teeth with initial caries lesions in enamel, at children under the age of 24 months. Clinical evaluation of initial carious lesions and its evaluation during the research was carried out using the International Caries Detection and Assessment System (ICDAS-II).

Results: There was a change of activity of the carious lesion in all three groups (CPP-ACPFG, FG and KG) during the time of treatment and follow-up, which was statistically significant. However, in the group of CPP-ACPFG, there was a better result compared to the FG and КG.

Conclusion: Remineralizing treatment of new generation varnish containing both  nanoapatite and fluоride gave a better result compared to conventional varnish with fluoride.


Fluor varnish, Casein PhosphoPeptide − Amorphous Calcium Phosphate, initial carious lesion, remineralization.

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