SYNERGISTIC EFFECTS OF LEAD-ACETATE AND ALLOXAN ON BODY WEIGHT GAIN AND ORGANOSOMATIC LIVER INDEX OF WISTAR RAT INFECTED WITH ESCHERICHIA

Abstract

Different agents, both biotic and abiotic, cause health changes in most vulnerable members of the human population. Diabetics, as very sensitive members of the population, are significantly more susceptible to bacterial infections, as well as to the toxic effect of certain pollutants. Alloxan is a common diabetogenic agens often used to induce experimental diabetes in laboratory rats, giving the clinical picture as type 1 diabetes in humans. The aim of this study was to determine common effects of lead-acetate and alloxan on body weight gain and organosomatic liver index of Wistar rat infected with escherichia. Significantly lower weight gain (p <0.05) was achieved by the test subjects exposed to bacterial infection, as well as by lead-acetate toxication. The negative value of this parameter was determined for the synergistic effect of the test substances. Values of organosomatic liver indexes showed a significant increase in diabetic rats exposed to infection in relation to the control group and rats treated with only one agens. In diabetic patients, hyperglycaemia may harm both innate and acquired immunity, thereby reducing resistance to pathogenic and associated illnesses. Environmental pollutants, including lead, can cause different changes in the body of a diabetic, so it is necessary to avoid any contact with this toxicant.