CHARACTERIZACION OF SKIN CANCER WITH OPTO-MAGNETIC IMAGING SPECTROSCOPY
Melanoma is the most malignant skin cancer in human population due to late detection, high invasiveness and rapid infiltration. Besides melanoma, skin cancer includes Basal cell cancer (BCC), Squamous cell cancer (SCC), and other rare cancers like Mercel cell carcinoma and Langerhans cell carcinoma. The annual increase of melanoma patients in Serbia is 6%, while this number in the rest of the world varies between 5% and 7%. Various techniques are used to detect and differentiate skin cancers; these techniques differ in the principle of operation and detection efficiency. A novel method is an opto-magnetic imaging spectroscopy (OMIS) based on light-tissue interaction. In more details, this technique measures the difference between responses of the skin when it is illuminated with white or polarized light under normal incidence or under Brewster angle. Different skin responses can also be measured under a fixed incident angle of the blue and the violet light. In this study, OMIS is used for detection and differentiation between simple mole (naevus) and melanoma, and for differentiation between non-melanoma cancer and melanoma. Investigations have included 65 patients with whom different lesions were confirmed by dermoscopy and histopathology. It is shown that good agreement between the results of the OMIS method and histopathological diagnosis were obtained in the sample covering 97% of the patients. This demonstrates that OMIS method can be one of the diagnostic methods for detection and differentiation of skin lesions.
 S. A. Miller, S. L. Hamilton, U. G. Wester, W. H. Cyr, An analysis of UVA emissions from sunlamps and the potential importance for melanoma, Photochem Photobiol, Vol. 68 (1998) 63−70.
 A. Schothorst, E. Enniga, J. Simons, Mutagenic effects per erythemal dose of artificial and natural sources of ultraviolet light. In: W. F. Passchier, B. F. M. Bosnjakovic, editors, Human exposure to ultraviolet radiation: risks and regulations; proceedings of a seminar held in Amsterdam, March 1987. New York: Excerpta Medica, 1987, p. 103−7.
 International Agency for Research on Cancer. IARC working group reports: exposure to artificial UV radiation and skin cancer. France: Lyon; 2006.
 F. El Ghissassi, R. Baan, K. Straif, Y. Grosse, B. Secretan, V. Bouvard, et al. WHO international agency for research on cancer monograph working group: a review of human carcinogens – part D: radiation, Lancet Oncol 10 (2009) 751–752.
 Cancer registry of central Serbia, cancer incidence and mortality in central Serbia, Institute of Public Health of Serbia „Dr Milan Jovanović Batut” Report No.11.
 L. Harvey, J. Zhao, D. McLean, et al. Real-time Raman Spectroscopy for In Vivo Skin Cancer Diagnosis, Cancer Res, Vol. 72 (2012) 2491−2500.
 M. Gniadecka, et al., Melanoma diagnosis by Raman spectroscopy and neural networks: structure alterations in proteins and lipids in intact cancer tissue, J Invest Dermatol, Vol. 122−2 (2004) 443−9.
 E. Salomatina, B. Jiang, J. Novak, A. N. Yaroslavsky, Optical properties of normal and cancerous human skin in the visible and near-infrared spectral range, J. Biomed. Opt., Vol. 11−6 (2006).
 Đ. Koruga, A. Tomić, System and Method for Analysis of Light-matter Interaction Based on Spectral Convolution, US Patent Pub. No.: 2009/0245603, Pub. Date: Oct. 1, 2009.
 D. Kojić, Karakterizacija strukturalnih, mehaničkih, električnih i magnetnih osobina kože pomoću optičkog i nanoprobe mikroskopa [Characterisation of structural, mechanical, electrical and magnetic properties of skin by optical and nanoprobe microscopy], Doctoral dissertation, Faculty of Mechanical Engineering, University of Belgrade, 2010 (in Serbian).
 G. Nikolić, I. Mileusnić, A. Tomić, Primena Optomagnetne spektroskopije u ranoj dijagnostici kancera kože u knjizi Rana dijagnostika epitelnih tkiva [Application of Opto-magnetic spectroscopy in early skin cancer diagnostics], pp. 375−396, in book Rana dijagnostika kancera epitelnog tkiva [Early cancer diagnostic of epithelial tissues], Ed. M. Papic-Obradovic, DonVas, Belgrade 2012 (in Serbian).
 Ð. Koruga, J. Bandić, G. Janjić, Č. Lalović, J. Munćan, D. Dobrosavljević Vukojević Epidermal Layers Characterisation by Opto-Magnetic Spectroscopy Based on Digital Image of Skin, Acta Physica Polonica A, Vol. 121−3 (2012) 606−610.