RETENTION BEHAVIOR AND BIOLOGICAL ACTIVITY OF N-SUBSTITUTED-2-PHENYLACETAMIDE DERIVATES

Authors

  • Đenđi Vaštag University of Novi Sad, Faculty of Science, Trg D. Obradovića 3, Novi Sad, Serbia
  • Suzana Apostolov University of Novi Sad, Faculty of Science, Trg D. Obradovića 3, Novi Sad, Serbia
  • Borko Matijević University of Novi Sad, Faculty of Science, Trg D. Obradovića 3, Novi Sad, Serbia
  • Jelena Nakomčić University of Novi Sad, Faculty of Science, Trg D. Obradovića 3, Novi Sad, Serbia
  • Aleksandar Marinković University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, Beograd, Serbia

DOI:

https://doi.org/10.7251/cm.v1i5.1508

Abstract

Phenylacetamide derivatives are a group of compounds that exhibit a wide range of biological activities as analgetic, anticonvulsant, pesticide, cytostatic. It is well known that the biological activity and the field of activity of the substance are greatly dependent on its physical, chemical and structural properties. In this paper, we applied QSRR analysis (Quantitative Structure Retention Relationships), which is based on the prediction of biological properties of compounds based on their chromatographic retention behaviors. To that end, retention constants of investigated N-substituted-2-phenylacetamide were determined by reversed phase thin-layer chromatography, (HPTLC RP18 F254s) in the presence of different volume fractions of n-propanol and tetrahydrofuran. The resulting data were correlated with molecular descriptors determined in different ways in order to establish the mathematical model that describes the relationship between retention properties and biological activities of investigated phenylacetamides.

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Published

2014-09-26