• Ana Todorović University of Belgrade, Faculty of Dental Medicine, Rankeova 4, 11000 Belgrade
  • Rebeka Rudolf University of Maribor, Faculty of Mechanical Engineering, Smetanova 17, 2000 Maribor
  • Nebojša Romčević University of Belgrade, Institute for Physics, Pregrevica 118, 11080 Belgrade
  • Igor Đorđević University of Belgrade, Faculty of Dental Medicine, Rankeova 4, 11000 Belgrade
  • Nataša Milošević University of Belgrade, Faculty of Dental Medicine, Rankeova 4, 11000 Belgrade
  • Branka Trifković University of Belgrade, Faculty of Dental Medicine, Rankeova 4, 11000 Belgrade
  • Valentina Veselinović University of Banja Luka, Faculty of Medicine, Save Mrkalja 14, 78000 Banja Luka
  • Miodrag Čolić Military Medicine Academy, Institute of Medical Research, Crnotravska 17, 11002 Belgrade



Shape memory alloys belong to a group of smart, functional materials with a unique ability to "remember" the shape that they had before the pseudo-elastic deformation. Cu-Al-Ni shape memory alloys are today the only available high-temperature SMA, showing good resistance to functional load, however their biomedical application is still limited. Using melt spinning technique, thin Cu-Al-Ni ribbons can be produced directly from the melt. The aim of our study was to evaluate the biocompatibility of Cu-Al-Ni alloys in vitro.

Thin Cu-Al-Ni ribbons were produced by the technique of melt spinning and used for the tests. The base alloy for casting of the same composition, but without shape memory effect, was used as control.

The results of MTT test showed that Cu-Al-Ni base alloys (alloys control) almost completely reduced metabolic activity of peripheral blood mononuclear cells (PBC), while none of Cu-Al-Ni ribbons types  showed a statistically significant effect on the metabolic activity of cells compared with control (cells cultivated only in the medium). Rapid solidified ribbons with memory effect stimulate the production of proinflammatory cytokines, but not Th1 and Th2 cytokines by activated PBC. However, in addition to IL-1β, their stimulatory potential is significantly lower compared to the control Cu-Al-Ni alloy.


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