USE OF PLATELET-RICH FIBRIN IN MAXILLOFACIAL SURGERY
DOI:
https://doi.org/10.7251/COMEN1601045TAbstract
Platelet Rich Fibrin (PRF) is autologous biomaterial which is the second-generation platelet concentrate. It has a favorable biological properties that accelerate healing of soft tissue, and bone, giveing a wide range of applications found in oral and maxillofacial surgery and other surgical fields.
PRF technique was developed by Choukroun et al in 2001 and it represents a second generation of autologous platelet concentrate, which is used to accelerate the healing of soft and hard tissue. In contrast to the PRP, the PRF is composed of autologous fibrin matrix in which a large amount of platelets and their growth factors are embedded. PRF-graft is used in augmentative techniques residual bone defects, alone or in combination with biomaterials. When the alveolar ridge augmentation technique GBR, the PRF membranes can be used for protection and stabilization of bone compensation. PRF accelerates the healing of soft tissue and reduces the possibility of dehiscence and exposure of the membrane.
References
J. Choukroun, A. Diss, A. Simonpieri, M. O. Girard, C. Schoeffler, S. L. Dohan, et al., Platelet-rich fibrin (PRF): a second-generation platelet concentrate, Part IV: clinical effects on tissue healing, Oral Surg Oral Med Oral Pathol Oral Radiol Endod., Vol. 101−3 (2006) 56–60.
J. Choukroun, A. Diss, A. Simonpieri, et al., Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift, Oral Surg Oral Med Oral Pathol. Oral Radiol. Endod., Vol. 101−3 (2006) 299−303.
D. M. Dohan Ehrenfest, T. Bielecki,
R. Jimbo, G. Barbe, M. Del Corso, F. Inchingolo, et al., Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF), Curr Pharm Biotechnol., Vol. 13−7 (2012) 1145–52.
D. M. Dohan, T. Ehrenfest Bielecki,
A. Mishra, P. Borzini, F. Inchingolo, G. Sammartino, et al., In search of a consensus terminology in the field of platelet concentrates for surgical use: plateletrich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes, Curr Pharm Biotechnol., Vol. 13−7 (2011) 1131–7.
T. Bielecki, D. M. Dohan Ehrenfest, Platelet-rich plasma (PRP) and plateletrich fibrin (PRF): surgical adjuvants, preparations for in situ regenerative medicine and tools for tissue engineering, Curr Pharm Biotechnol., Vol. 13−7 (2012) 1121–1130.
T. Bielecki, D. M. Dohan Ehrenfest, Leukocyte and platelet-rich plasma (L-PRP)/fibrin (L-PRF) in medicine past, present, future, Curr Pharm Biotechnol., Vol. 13−7 (2012) i–ii.
B. Chignon-Sicard, C. A. Georgiou,
E. Fontas, S. David, P. Dumas, T. Ihrai, et al., Efficacy of leukocyte- and platelet-rich fibrin in wound healing: a randomized controlled clinical trial, Plast Reconstr Surg., Vol. 130−6 (2012) 819e–29e.
F. M. Huang, S. F. Yang, J. H Zhao, Y. C. Chang, Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells, J Endod., Vol. 36−10 (2010) 1628–32.
C. L. Wu, S. S. Lee, C. H. Tsai, K. H. Lu, J. H. Zhao, Y. C. Chang, Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts, Aust Dent J., Vol. 57−2 (2012) 207–12.
S. Jankovic, Z. Aleksic, P. Klokkevold, V. Lekovic, B. Dimitrijevic, E. B. Kenney, et al., Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial, Int J Periodontics Restorative Dent., Vol. 32−2 (2012) e41–50.
S. Jankovic, Z. Aleksic, I. Milinkovic,
B. Dimitrijevic, The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study, Eur J Esthet Dent., Vol. 5−3 (2010) 260–273.
S. Aroca, T. Keglevich, B. Barbieri,
I. Gera, D. Etienne, Clinical evaluation of a modi-fied coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study, J Periodontol., Vol. 80−2 (2009) 244–252.
A. R. Pradeep, N. S. Rao, E. Agarwal,
P Bajaj, M. Kumari, S. B Naik, Comparative evaluation of autologous plateletrich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial, J Periodontol., Vol. 83−12 (2012) 1499–1507.
M. Thorat, A. R. Pradeep, B. Pallavi, Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial, J Clin Periodontol., Vol. 38−10 (2011) 925–932.
A. Sharma, A. R. Pradeep, Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol., Vol. 82−12 (2011) 1705–1712.
A. Sharma, A. R. Pradeep, Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial, J Periodontol., Vol. 82−10 (2011) 1396–1403.
V. Lekovic, I. Milinkovic, Z. Aleksic,
S. Jankovic, P. Stankovic, E. B. Kenney, et al., Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects, J Periodontal Res., Vol. 47−4 (2012) 409–417.
A. Simonpieri, J. Choukroun, M. del Corso, G. Sammartino, D. M. Dohan Ehrenfest, Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience, Implant Dent., Vol. 20−1 (2011) 2–12.
M. Del Corso, A. Vervelle, A. Simonpieri, R. Jimbo, F. Inchingolo, G. Sammartino, et al., Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery, Curr Pharm Biotechnol., Vol. 13−7 (2012) 1207–1230.
D. M. Dohan Ehrenfest, L. Rasmusson, T. Albrektsson, Classification of platelet concentrates: from pure plateletrich plasma (P-PRP) to leucocyte- and platelet- rich fibrin (L-PRF), Trends Biotechnol., Vol. 27−3 (2009) 158–167.
A. Simonpieri, M. Del Corso, G. Sam-martino, D. M. Dohan Ehrenfest, The relevance of Choukroun’s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol, Implant Dent., Vol. 18−2 (2009) 102–111.
M. del Corso, Z. Mazor, J. L. Rutkowski, D. M. Dohan Ehrenfest, The use of leukocyte- and platelet-rich fibrin during immediate postextractive implantation and loading for the esthetic replacement of a fractured maxillary central incisor. J Oral Implantol, Vol. 38−2 (2012) 181–7.om
R. J. Carroll, S. P. Arnoczky, S. Graham, S. M. O’Connell, Characterization of autologous growth factors in Cas-cade platelet-rich fibrin matrix (PRFM), Edison, NJ: Musculoskeletal Transplant Foundation 2005.
A. Cieslik-Bielecka, D. M. Dohan Ehrenfest, A. Lubkowska, T. Bielecki, Microbicidal properties of leukocyte- and platelet-rich plasma/fibrin (L-PRP/ L-PRF): new perspectives, J Biol Regul Homeost Agents., Vol. 26−2/1 (2012) 43S–52S.
J. Choukroun, A. Diss, A. Simonpieri, et al., Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift, Oral Surg Oral Med Oral Pathol. Oral Radiol. Endod., Vol. 101−3 (2006) 299−303.
D. M. Dohan Ehrenfest, T. Bielecki,
R. Jimbo, G. Barbe, M. Del Corso, F. Inchingolo, et al., Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF), Curr Pharm Biotechnol., Vol. 13−7 (2012) 1145–52.
D. M. Dohan, T. Ehrenfest Bielecki,
A. Mishra, P. Borzini, F. Inchingolo, G. Sammartino, et al., In search of a consensus terminology in the field of platelet concentrates for surgical use: plateletrich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes, Curr Pharm Biotechnol., Vol. 13−7 (2011) 1131–7.
T. Bielecki, D. M. Dohan Ehrenfest, Platelet-rich plasma (PRP) and plateletrich fibrin (PRF): surgical adjuvants, preparations for in situ regenerative medicine and tools for tissue engineering, Curr Pharm Biotechnol., Vol. 13−7 (2012) 1121–1130.
T. Bielecki, D. M. Dohan Ehrenfest, Leukocyte and platelet-rich plasma (L-PRP)/fibrin (L-PRF) in medicine past, present, future, Curr Pharm Biotechnol., Vol. 13−7 (2012) i–ii.
B. Chignon-Sicard, C. A. Georgiou,
E. Fontas, S. David, P. Dumas, T. Ihrai, et al., Efficacy of leukocyte- and platelet-rich fibrin in wound healing: a randomized controlled clinical trial, Plast Reconstr Surg., Vol. 130−6 (2012) 819e–29e.
F. M. Huang, S. F. Yang, J. H Zhao, Y. C. Chang, Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells, J Endod., Vol. 36−10 (2010) 1628–32.
C. L. Wu, S. S. Lee, C. H. Tsai, K. H. Lu, J. H. Zhao, Y. C. Chang, Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts, Aust Dent J., Vol. 57−2 (2012) 207–12.
S. Jankovic, Z. Aleksic, P. Klokkevold, V. Lekovic, B. Dimitrijevic, E. B. Kenney, et al., Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial, Int J Periodontics Restorative Dent., Vol. 32−2 (2012) e41–50.
S. Jankovic, Z. Aleksic, I. Milinkovic,
B. Dimitrijevic, The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study, Eur J Esthet Dent., Vol. 5−3 (2010) 260–273.
S. Aroca, T. Keglevich, B. Barbieri,
I. Gera, D. Etienne, Clinical evaluation of a modi-fied coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study, J Periodontol., Vol. 80−2 (2009) 244–252.
A. R. Pradeep, N. S. Rao, E. Agarwal,
P Bajaj, M. Kumari, S. B Naik, Comparative evaluation of autologous plateletrich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial, J Periodontol., Vol. 83−12 (2012) 1499–1507.
M. Thorat, A. R. Pradeep, B. Pallavi, Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial, J Clin Periodontol., Vol. 38−10 (2011) 925–932.
A. Sharma, A. R. Pradeep, Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol., Vol. 82−12 (2011) 1705–1712.
A. Sharma, A. R. Pradeep, Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial, J Periodontol., Vol. 82−10 (2011) 1396–1403.
V. Lekovic, I. Milinkovic, Z. Aleksic,
S. Jankovic, P. Stankovic, E. B. Kenney, et al., Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects, J Periodontal Res., Vol. 47−4 (2012) 409–417.
A. Simonpieri, J. Choukroun, M. del Corso, G. Sammartino, D. M. Dohan Ehrenfest, Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience, Implant Dent., Vol. 20−1 (2011) 2–12.
M. Del Corso, A. Vervelle, A. Simonpieri, R. Jimbo, F. Inchingolo, G. Sammartino, et al., Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery, Curr Pharm Biotechnol., Vol. 13−7 (2012) 1207–1230.
D. M. Dohan Ehrenfest, L. Rasmusson, T. Albrektsson, Classification of platelet concentrates: from pure plateletrich plasma (P-PRP) to leucocyte- and platelet- rich fibrin (L-PRF), Trends Biotechnol., Vol. 27−3 (2009) 158–167.
A. Simonpieri, M. Del Corso, G. Sam-martino, D. M. Dohan Ehrenfest, The relevance of Choukroun’s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol, Implant Dent., Vol. 18−2 (2009) 102–111.
M. del Corso, Z. Mazor, J. L. Rutkowski, D. M. Dohan Ehrenfest, The use of leukocyte- and platelet-rich fibrin during immediate postextractive implantation and loading for the esthetic replacement of a fractured maxillary central incisor. J Oral Implantol, Vol. 38−2 (2012) 181–7.om
R. J. Carroll, S. P. Arnoczky, S. Graham, S. M. O’Connell, Characterization of autologous growth factors in Cas-cade platelet-rich fibrin matrix (PRFM), Edison, NJ: Musculoskeletal Transplant Foundation 2005.
A. Cieslik-Bielecka, D. M. Dohan Ehrenfest, A. Lubkowska, T. Bielecki, Microbicidal properties of leukocyte- and platelet-rich plasma/fibrin (L-PRP/ L-PRF): new perspectives, J Biol Regul Homeost Agents., Vol. 26−2/1 (2012) 43S–52S.
Downloads
Published
2017-12-27
Issue
Section
Articles