Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3‐Diphenyl‐1,3‐propanedione

Abstract

Schiff bases are organic compounds formed by the reaction of the primary amine
with carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentate
ligands capable of forming very stable complexes with transitional metals. They are
used as catalysts in oxygenation, hydrolysis, electro-reduction and decomposition
reactions. Many Shiff bases show significant anti-tumor, antimicrobial and antifungal
activity, which are the subject of research by many scientists in the world.
In this paper Schiff base from benzidine and 1,3-diphenyl-1,3-propanedione was
synthesized. To characterize the product, FTIR spectroscopy and stereo-microscopy
were used. In order to determine biological activity, antibacterial, antifungal and
antioxidant activity of the product was tested.
The results showed that the interaction of benzidine and 1,3-diphenylpropanedione
results in a Schiff base showing antibacterial, antifungal and antioxidant activity.