Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3‐Diphenyl‐1,3‐propanedione


  • Emir Horozić
  • Jasmin Suljagić
  • Darja Husejnagić
  • Nusreta Hasić
  • Amra Bratovčić



Schiff bases are organic compounds formed by the reaction of the primary amine
with carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentate
ligands capable of forming very stable complexes with transitional metals. They are
used as catalysts in oxygenation, hydrolysis, electro-reduction and decomposition
reactions. Many Shiff bases show significant anti-tumor, antimicrobial and antifungal
activity, which are the subject of research by many scientists in the world.
In this paper Schiff base from benzidine and 1,3-diphenyl-1,3-propanedione was
synthesized. To characterize the product, FTIR spectroscopy and stereo-microscopy
were used. In order to determine biological activity, antibacterial, antifungal and
antioxidant activity of the product was tested.
The results showed that the interaction of benzidine and 1,3-diphenylpropanedione
results in a Schiff base showing antibacterial, antifungal and antioxidant activity.