Effect of use of insulin pump with low glucose suspend feature on metabolic control in children with type 1diabetes

Abstract

Introduction. The automatic suspension of the insulin pump and discontinuation
of insulin delivery in case of hypoglycemia is one of the features of
Veo insulin pump when it is connected with the sensor used for continuous
monitoring of glycemia (CGM). This type of therapy is currently considered
to be the best one for achieving a good metabolic control in children with
type 1 diabetes mellitus. The objective of the study was to check whether
the use of an option for automatic suspension in case of hypoglycemia and
combined bolus affects the metabolic control in children with type 1 diabetes
mellitus using the insulin pump for a three-month period.
Methods. The study included 25 participants (13 girls and 12 boys), aged
7 to 15 years with average age 11.88 ± 3.15 years and average diabetes duration
of 6.12 ± 2.5 years. On average, the participants have already been
using the insulin pump Paradigm Veo TM MMT-754 for 3.08 ± 1.73 years.
The measurements of HbA1c were done at the beginning of the study, then
after three and six months.
Results. The percentage of glucose serum levels above 7.8 mmol/L insignificantly
increased, while the percentage of glucose serum levels below
3.9 mmol/L decreased during the three-month period of CGM wearing.
The initial HbA1c was 7.53 ± 0.87%. After three months of wearing, CGM
HbA1c showed a slight decrease to 7.48 ± 0.73%, while at the follow-up after
another three months without CGM HbA1c increased to 7.57 ± 0.98%.
Conclusion. This study shows that the use of an insulin pump with the option
of automatic suspension in case of hypoglycemia and combined bolus
is only associated with a certain improvement in the metabolic control
after three months of continuous wearing without increasing the risk of
hypoglycemia.