Analysis of Ambroxol Hydrochloride in Flavamed® Tablets by Means of Spectroscopic Absorption Methods

Authors

  • Dijana Jelić University of Banja Luka, Medical faculty, Pharmacy Department, Banja Luka
  • Saida Fazlagić University of Banja Luka, Medical faculty, Pharmacy Department, Banja Luka
  • Vesna Antunović University of Banja Luka, Medical faculty, Pharmacy Department, Banja Luka
  • Nataša Bubić-Pajić University of Banja Luka, Medical faculty, Pharmacy Department, Banja Luka
  • Anđelka Račić University of Banja Luka, Medical faculty, Pharmacy Department, Banja Luka
  • Mirjana Đermanović Institute of Public Health of Republic of Srpska, Banja Luka

DOI:

https://doi.org/10.7251/QOL1601024J

Abstract

Ambroxol hydrochloride (AMB), (1s,4s)-4-((2-amino-3,5-dibromocyclohexyl)methylamino) cyclohexanol hydrochloride, is semi - synthetic derivative of vasicine obtained from Indian shrub Adhatoda vasica. It is a metabolic product of bromhexin and it is used as broncho secretolytic and an expectorant drug. Analysis of Flavamed® tablets, in which ambroxol hydrochloride (AMB) is an active component, was performed. UV/VIS spectrophotometry and atomic absorption spectroscopy (AAS) were used. Direct and indirect UV/VIS spectrophotometric methods were used for quantitative analysis of AMB and the following recovery value results were obtained: 100,16% and 95,23%, successively. Content of heavy metals in Flavamed® tablets was determined by atomic absorption spetroscopy.

Downloads

Published

2016-06-30

Issue

Vol. 13 No. 1-2 (2016): QUALITY OF LIFE (Banja Luka) - APEIRON

Section

Чланци